Web13 Funding:This study was supported by the National High Technology Research and Development Program of China (201 14 3AA102902), the National Key Technology Support Program of China (2012BAD09B03), and the “111” Project of Chin 15 ese Education Ministry (B12007). available under aCC-BY 4.0 International license. Webylcellulose (HPMc) solution (w/v) (Shanghai ryon Biological Technology o., ctd.) every day prior to use. Following l 7 days of acclimatization, rats were randomly divided into a control group, which was administered with 1%c, HPM and five test groups that were administered with different concentrations of copper by gavage for 28 days: i) 200 mg/kg

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