Web12 okt. 2010 · Lithium is licensed for the acute treatment of mania, prophylaxis in bipolar disorder and to augment antidepressants in treatment-refractory recurrent depression. Its use for these indications is supported by contemporary UK treatment guidelines [ 1 – 3 ]. For most patients, treatment with lithium is long term [ 4 ]. Web20 feb. 2024 · This drug should be considered a narrow therapeutic index (NTI) drug as small differences in dose or blood concentrations may lead to serious therapeutic …
Lithium side effects and toxicity: prevalence and ... - SpringerOpen
Web1 feb. 2013 · Lithium has a relatively narrow therapeutic index so it is important to maintain lithium plasma concentrations within a specific range for each individual to … Web24 okt. 2024 · Unfortunately, lithium has a narrow therapeutic index, and toxic effects are apparent at concentrations of ≥ 1.4 mmol/L ≥ 1.4 mmol / L, which can include renal failure, seizures, coma, and even death. 6 Toxicity can occur suddenly as a result of rapid buildup of lithium concentrations (overdose, drug interactions, and physical illness) or due to … holiday inn express maybrook ny
FDA Drug Topics: Understanding Generic Narrow Therapeutic …
WebLithium Toxicity Pharmacokinetics Lithium is a small, positively charged ion. Narrow therapeutic index (0.8-1.2 mEq/L); many patients on lithium for long periods of time will endure a toxic event at least once during their treatment. Absorbed … Web7 jun. 2024 · We have often heard the term “therapeutic index” or “therapeutic window” of some drugs, typically in the sense of noting that some of our medications have a “ low … WebLithium is a mood-stabilizing drug often used to treat bipolar disorder. It has a narrow therapeutic index, so side effects are commonly seen with its use. Side effects of lithium include hypothyroidism, neuromuscular excitations like … hugh stafford smith