Epcam biology

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August undefined, 2024

WebSep 5, 2024 · Cell-surface tumor marker EpCAM plays a key role in proliferation, differentiation and adhesion processes in stem and epithelial cells. It is established as a cell-cell adhesion molecule, forming... WebFeb 15, 2015 · Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein, which is frequently and highly expressed on carcinomas, tumor-initiating cells, selected tissue progenitors, and embryonic and adult stem cells. During liver development, EpCAM demonstrates a dynamic expression, since it can be detected in fetal liver, …

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WebNov 13, 2024 · Epithelial cell adhesion molecule (EpCAM) is the most frequently expressed tumor-associated antigen; it is overexpressed in the majority of human … Epithelial cell adhesion molecule (EpCAM), also known as CD326 among other names, is a transmembrane glycoprotein mediating Ca -independent homotypic cell–cell adhesion in epithelia. EpCAM is also involved in cell signaling, migration, proliferation, and differentiation. Additionally, EpCAM has … See more First discovered in 1979, EpCAM was initially described as a dominant surface antigen on human colon carcinoma. Because of its prevalence on many carcinomas, it has been "discovered" many different … See more The exact function of EpCAM is currently being elucidated, but EpCAM appears to play many different roles. Cell adhesion EpCAM was first … See more • FAQs on HNPCC Archived 15 August 2007 at the Wayback Machine from the National Institute of Health • GeneReviews/NCBI/NIH/UW entry on Lynch syndrome See more Although it is identified as a cell adhesion molecule, EpCAM does not structurally resemble any of the four major families of cell adhesion molecules, namely cadherins, integrins, selectins, and members of the immunoglobulin super-family. EpCAM is a See more Target for immunotherapy It has been speculated that since EpCAM in normal epithelia is expressed mostly on the basolateral membrane, it would be much less … See more intin litmaset

EpCAM and the biology of hepatic stem/progenitor cells

WebSep 27, 2024 · Here, we addressed the expression and function of the therapeutic target epidermal growth factor receptor (EGFR) and of the major determinant of epithelial differentiation epithelial cell adhesion molecule (EpCAM) in clinical samples and in vitro models of HNSCCs. WebJan 6, 2024 · In this perspective, we thought of investigating epithelial cell adhesion molecule (EpCAM) as a potential molecule. EpCAM is a CSC surface marker that was … WebFeb 15, 2015 · EpCAM is a transmembrane glycoprotein, which is primarily expressed in simple epithelia, progenitor cells, normal and malignant stem cells, as well as in … new la law cast

EpCAM homo-oligomerization is not the basis for its role in

Nuclear signalling by tumour-associated antigen EpCAM

WebOct 25, 2010 · EpCAM has been long known as a tumor-associated antigen highly expressed in a variety of carcinomas (Koprowski et al., 1979).It is used as a marker for aggressive tumors, and has been considered as a potential target for immunotherapy (Osta et al., 2004).In human and mouse, EpCAM is expressed in embryonic epithelia, but the … new lake village apartments henryettaWebof EpCAM expression with prognosis in different cancers is supported by functional studies of EpCAM biology using in vitro and in vivo cancer models as well. Taken together these studies suggest that the impact of EpCAM expres-sion in human cancers is likely to be context dependent [28]. EpCAM expression based assay has been FDA ap- int in math

"WebApr 4, 2024 · Journal Metrics. Communications Biology has a 2-year impact factor: 6.548 (2024), article downloads of 4,666,583 (2024) and 11 days from submission to the first editorial decision. " - Epcam biology

Epcam biology

Biology and clinical relevance of EpCAM - PMC - National Center …

WebJan 11, 2009 · Our finding that EpCAM is a potent signal transducer that uses components of the Wnt pathway, with a proven significance for tumour development and cell renewal … WebThe EPCAM gene provides instructions for making a protein known as epithelial cellular adhesion molecule (EpCAM). This protein is found in epithelial cells, which are the cells …

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WebEpCAM is a transmembrane glycoprotein that is a member of the cell adhesion molecule (CAM) family of proteins. This marker is expressed by normal epithelial cells and has been found to be expressed in up to 70% of all primary carcinoma tumor types ( Went et al., 2004 ). EpCAM has been utilized as a tool for CTC enrichment, as epithelial cells ... WebAbstract: The epithelial cell adhesion molecule (EpCAM, CD326) is a glycoprotein of ∼40 kd that was originally identified as a marker for carcinoma, attributable to its high expression on rapidly proliferating tumors of epithelial origin. Normal epithelia express EpCAM at a variable but generally lower level than carcinoma cells. In early studies, EpCAM was …

WebNov 11, 2024 · EpCAM is a single-chain membrane-spanning protein consisting of three major domains, termed EpEX, transmembrane domain (TM) and EpICD (Fig. 1 ). EpEX … WebMay 31, 2024 · EpCAM, a carcinoma cell-surface marker protein and a therapeutic target, has been primarily addressed as a cell adhesion molecule. With regard to recent …

WebAug 5, 2024 · EpCAM is a cell-surface transmembrane glycoprotein that is expressed in healthy human epithelial tissues but also in epithelial cancers, cancer stem cells, and … WebFeb 13, 2024 · Epithelial cell adhesion molecule (EpCAM) is expressed at the basolateral membrane of most normal epithelial cells but is overexpressed in many epithelial cancers.

WebEpCAM: structure and function in health and disease. Injection of tumor cells in mice more than 30 years ago resulted in the discovery of an epithelial antigen, later defined as a cell adhesion molecule (EpCAM). Although EpCAM has since evoked significant interest as a target in cancer therapy, mechanistic insights on the functions of this ...

WebMay 31, 2024 · EpCAM (CD326) is a conserved type I transmembrane glycoprotein of 35 kDa expressed on epithelial cells of higher eukaryotes. It was initially discovered as a … int in mpmcWebMay 12, 2024 · EpCAM (Epithelial cell adhesion molecule) is often dysregulated in epithelial cancers. Prior studies implicate EpCAM in the regulation of oncogenic signaling … intinnWebEpithelial Cell Adhesion Molecule. The epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein which is typically expressed by cancers originating from epithelial tissue [94–97], and not expressed in hematological cells. From: Advances in Clinical Chemistry, 2024. Related terms: T Cell; Cancer Stem Cell; CD44; CD133 new lambton publicWebThe epithelial cell adhesion molecule (EpCAM, also designated TACSTD1, CD326) is a type I transmembrane protein of 314 ... Taken together, these studies suggest that the impact of EpCAM expression on cancer biology may be context-dependent (reviewed in van der Gun et al, 2010). Breast cancer is a heterogeneous disease. Recent advances in int in mysql lengthWebAug 1, 2013 · EpCAM is a cell surface glycoprotein of approximately 40 kDa (detailed below) that is highly expressed in epithelial cancers and at lower levels in normal simple … new lambo truckWebMar 31, 2024 · Each discovery in RNA biology [e.g., primer in CRISPR (7, 8), ... Development of a bifunctional aptamer targeting the transferrin receptor and epithelial cell adhesion molecule (EpCAM) for the … intin meaningWebNov 15, 2024 · At TJ break sites, EpCAM–claudin-7 complexes on the basolateral membrane become accessible to apical membrane-anchored serine proteinases (MASPs) and the MASPs cleave EpCAM. … new lake worth high school