Cisplatin electrolyte abnormalities
WebCisplatin for injection is a highly emetogenic antineoplastic agent; premedicate with anti-emetic agents; without antiemetic therapy, marked nausea and vomiting occur in almost all patients treated with cisplatin … WebNational Center for Biotechnology Information
Cisplatin electrolyte abnormalities
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Webcisplatin, and was severe in 20%. Monitor patients for hypomagnesemia, hypocalcemia, and hypokalemia prior to each dose of PORTRAZZA during treatment and for at least 8 weeks following completion of PORTRAZZA. Withhold PORTRAZZA for Grade 3 or 4 electrolyte abnormalities. Replete electrolytes as medically appropriate. (5.2) WebCisplatin causes hypomagnesemia in a dose-dependent fashion and affects up to 90% of patients if no preventive measures are taken ... Hypomagnesemia is the most common electrolyte abnormality related to chronic alcohol abuse and affects as many as 30% of alcohol-dependent patients. 148, ...
WebJan 1, 2015 · Majority of electrolyte abnormalities were grade 1 for all the four electrolytes. Grade 3 (15.3%) and Grade 4 (2.4%) was seen predominantly for sodium. There were no grade 3 or 4... WebNational Center for Biotechnology Information
WebDec 16, 2024 · However, cisplatin-induced nephrotoxicity is a major dose-limiting factor and a significant adverse event. Mannitol is used to reduce cisplatin-induced nephrotoxicity, which is controversial. ... Diuretics contribute to electrolyte disorders, often promoting the excretion of electrolytes into urine by the kidneys. In this meta … WebCisplatin is a coordinate metal complex with significant antineoplastic activity and various effects, including acute anc chronic renal insufficiency and renal magnesium …
WebSep 27, 2024 · Nephrotoxicity: cisplatin for injection can cause severe renal toxicity, including acute renal failure. Severe renal toxicities are dose-related and cumulative. Ensure adequate hydration and monitor renal function and electrolytes.
WebManufacturer advises cisplatin requires intensive intravenous hydration and treatment may be complicated by severe nausea and vomiting. ... Side-effects Side-effects For cisplatin. Common or very common. Anaemia; arrhythmias; bone marrow failure; electrolyte imbalance; extravasation necrosis; fever; leucopenia; nephrotoxicity (dose-related and ... how many canyons are in arizonaWebApr 15, 2016 · 3. Platinum-containing drugs (cisplatin, carboplatin and oxaliplatin) Cisplatin, carboplatin and oxaliplatin are platinum-containing anticancer drugs targeting solid cancers, such as head and neck cancer, lung cancer, and cervical cancer (Ali et al., 2013).The use of these drugs has been associated with a number of electrolyte … high river medical supply centreWebSep 15, 2024 · Deafness after the initial dose of cisplatin (cisplatin injection) has been reported rarely. Ototoxic effects may be more severe in children receiving cisplatin … high river medical supplyWebmay drive unique electrolyte disorders in different malignancies. In the next sections, the clinical fea-tures, pathophysiology, and treatment of the most … high river medical centreWebMay 18, 2024 · Compared with young patients, the incidences of cisplatin-induced nephrotoxicity and acute kidney injury (AKI) in elderly patients are significantly increased, … high river medical supply storeWebOct 19, 2024 · Severe electrolyte abnormalities (secondary exposure) included ≥ grade three hypophosphatemia, hypokalemia, or hypomagnesemia (National Cancer Institute Common Terminology Criteria for Adverse Events v4.0). CKD was albuminuria or decreased kidney function for age (KDIGO guidelines). high river mental health clinicWeb• Hypomagnesemia and Accompanying Electrolyte Abnormalities: Monitor during treatment and for at least 8 weeks following the completion. Replete electrolytes as necessary. (5.6) ... and Cisplatin . 5.6 Hypomagnesemia and Accompanying Electrolyte Abnormalities . 5.7 Increased Tumor Progression, Increased Mortality, or Lack ... high river minor hockey association