WebMay 4, 2024 · CIB2 is a Ca 2+ - and Mg 2+ -binding protein essential for mechanoelectrical transduction (MET) by cochlear hair cells, but not by vestibular hair cells that co-express … WebMar 31, 2024 · Cib2 and Cib3 transcripts are highly expressed in the striolar and extrastriolar regions, respectively. Stereocilia maintenance and balance function are …
CIB2 and CIB3 are auxiliary subunits of the mechanotransduction …
WebIn this study, three other members of this protein family (CIB2-4: CIB2, CIB3, and CIB4) were purified and subsequently characterized using biophysical and structural approaches. As expected from sequence alignments, CIB2-4 were shown to bind calcium (Ca(2+)) and magnesium (Mg(2+)) ions. Binding of Ca(2+) or Mg(2+) ions changes the secondary ... WebFeb 9, 2024 · Stable neural function requires an energy supply that can meet the intense episodic power demands of neuronal activity. Neurons have presumably optimized the volume of their bioenergetic machinery to ensure these power demands are met, but the relationship between presynaptic power demands and the volume available to the … shower chair post surgery
Loss of CIB2 Causes Profound Hearing Loss and Abolishes ...
WebBy determining the crystal structures of CIB3 and its complex with a TMC1- peptide, we were able to visualize the molecular determinants that allow CIB3 to interact with itself and TMC1. We demonstrate that CIB2 mutations affect the single channel conductance of the MET channel, indicating that CIB2 is a regulator of the MET complex. WebMar 29, 2024 · HIV-1 replication, specifically viral entry, requires CIB1 and CIB2 expression as shRNA knockdown of each impairs replication in Jurkat and primary CD4+ T cells. Screening in Jurkat T-cells with a short-hairpin-RNA (shRNA) library identifies calcium and integrin binding family member 2 (CIB2) is important for HIV-1 replication. WebMar 31, 2024 · Cib2 and Cib3 transcripts are highly expressed in the striolar and extrastriolar regions, respectively. Stereocilia maintenance and balance function are … shower chair or tub bench